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Systems Biology

Course code
ELL707
L-T-P
3-0-0
Credits
3
MODELS : Variables and parameters, Law of mass action, Representations : Deterministic vs stochastic, Spatial aspects, Examples of core processes: Gene expression, Protein degradation, Phosphorylation.|DYNAMICS : Equilibrium solutions, Bifurcations, Switches, Bistability, Pulses and Oscillations, Circadian Rhythms and Clocks, Spatial patterns. Morphogenesis and Development.|CONTROL MECHANISMS : Performance Goals, Integral Feedback Control, Homeostasis and Perfect Adaptation, Bacterial Chemotaxis, Feedforward Loops, Fold Change Detection, Robustness to Perturbations, Tradeoffs, Internal Model Principle.

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